Beilstein J. Org. Chem.2019,15, 2941–2947, doi:10.3762/bjoc.15.289
polyketide; Fusarium; marinefungus; secondary metabolite; sponge; Introduction
Marine organisms have been known as a potential source of prospective bioactive compounds, and sponges are particularly emphasized as the most promising source among all marine invertebrates [1][2]. However, the collection of
Beilstein J. Org. Chem.2014,10, 1017–1022, doi:10.3762/bjoc.10.101
cyclic depsipeptide is sansalvamide A (San A, Figure 1) [20][21][22][23][24][25][26][27][28][29], which was isolated from a marinefungus (Fusarium spp.) [20] and exhibits antitumor activity against multiple cancer cell lines. It is cytotoxic against colon (HCT-116) [20][23][25][26], pancreatic (S2-013
PDF
Graphical Abstract
Figure 1:
Sansalvamide A (1) and its depsipeptoid analogues (2).